Pharmacology Introduction

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• Overview of Pharmacology

• New Animal Drugs, Extralabel Drug Use, Compounded Drugs, and Generic Drugs

• Disposition and Fate of Drugs
  • Passage of Drugs Across Cell Membranes
  • Drug Absorption
    • Absorption From the GI Tract
    • Absorption From Topical Administration
    • Absorption From Tracheobronchial Surfaces and Alveoli
    • Absorption From Injection Delivery Sites
    • Drug Bioavailability
  • Drug Distribution
  • Drug Metabolism
  • Drug Excretion
    • For More Information

• Pharmacokinetics
  • Apparent Volume of Distribution
  • Drug Clearance
    • Elimination Rate Constant
    • Single-Dose Concentration Curves After Extravascular Administration
    • Steady-State Plasma Concentration (Repeated Administration or Constant IV Infusion)

• Drug Action in Animals : Pharmacodynamics
  • Protein-Mediated Mechanisms of Drugs
  • Non–Protein-Mediated Mechanisms of Drugs
  • Receptor-Mediated Signal Transduction
  • Drug-Receptor Binding
  • Log-Dose Effect Relationship
  • Receptor Agonists
  • Understanding Drug-Receptor Transduction
  • Antagonists
  • Noncompetitive Antagonists
  • Agonist/Antagonists
  • Inverse Agonists
  • Receptor Phenomena of Clinical Relevance
    • Hyporeactivity or Tolerance
    • Rapid Loss of Drug Effect: Tachyphylaxis
    • Loss of Drug Effect: Receptor Desensitization and Downregulation, and Exhaustion of Mediators
    • Hyperreactivity
    • Spare Receptors
  • Key Points
  • For More Information

• Routes of Administration and Dosage Forms of Drugs
  • Oral Route of Administration and Dosage Forms
  • Oral Modified-release Delivery Systems for Ruminants
  • Parenteral Route of Administration and Dosage Forms
    • Special Dosage Form Considerations With Intra-articular Injections
  • Special Dosage Form Considerations With Recombinant Proteins and Peptides
  • Special Dosage Form Considerations With Live Vaccines, Inactivated and Subunit Vaccines, and DNA Vaccines
  • Topical Route of Administration and Dosage Forms
    • Specialized Topical Dosage Forms and Transdermal Delivery Systems
  • Specialized Topical Dosage Forms, Delivery Systems, and Application Methods for Parasite Control
  • Inhaled Delivery Systems and Dosage Forms

• Chemical Residues in Animal Source Foods and Animal Fiber
  • Chemical Residues in Foodstuffs of Animal Origin
    • Residues Resulting from Veterinary Drugs, Medicated Feeds, or Application of Pesticides
    • Residues Resulting from Consumption of Feedstuffs Treated with Agricultural Chemicals
  • Chemical Residues in Animal Fibers