Dosages of Polyene Macrolide Antibiotics
Dosages of Polyene Macrolide Antibiotics
Polyene Macrolide | Dosage, Route, and Frequency |
|---|---|
Amphotericin B (0.1 mg/mL in 5% dextrose) | 0.1–1 mg/kg, given IV slowly, 3 times/wk Total dose: 4–11 mg/kg |
Amphotericin B lipid complex injection (Abelcet®) | 1–3 mg/kg, IV, every other day or 3 times/wk Total dose: 12–24 mg/kg |
Amphotericin B liposome (AmBisome®) | 3– 4 mg/kg, IV, every other day or 3 times/wk Total dose: 12–30 mg/kg |
Nystatin | 50,000–150,000 U, PO, tid (dogs) |
Pimaricin (5% ophthalmic solution) | 1 drop, instilled into the eye, every 1–2 hr |