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Degenerative Diseases of the Spinal Column and Cord


William B. Thomas

, DVM, MS, DACVIM (Neurology), University of Tennessee

Last full review/revision Oct 2013 | Content last modified Oct 2013
Topic Resources

Cervical Spondylomyelopathy:

Cervical spondylomyelopathy, also called cervical vertebral malformation-malarticulation and wobbler syndrome, is compression of the spinal cord caused by abnormal development of the cervical vertebrae. Genetic factors and possibly nutrition may be involved.

In dogs, there are two forms of the disease, disc-associated wobbler syndrome (DAWS) and bony-associated cervical spondylomyelopathy. DAWS affects middle-aged (mean 7 yr), large-breed dogs, especially Doberman Pinschers. There is ventral compression of the spinal cord due to protrusion of one or more caudal cervical discs, in some cases complicated by congenital stenosis of the vertebral canal or hypertrophy of the ligamentum flavum. Bony-associated compression affects young (several months to 4 yr), giant-breed dogs, including Great Danes, Mastiffs, and Rottweilers. Spinal cord compression is due to bony proliferation of the articular processes and pedicles, usually of the C4 to C7 vertebrae.

Clinical signs can be acute or slowly progressive. Mild cases are characterized by subtle ataxia of all limbs, often evident as a long, protracted stride in the pelvic limbs, with short-strided gait in the thoracic limbs. In severe cases, there is paresis or paralysis of all limbs. Neck pain is variable. Differential diagnoses include congenital anomalies, trauma, meningomyelitis, discospondylitis, and neoplasia. Survey radiographs cannot confirm a diagnosis of cervical spondylomyelopathy but are useful in excluding discospondylitis and bony neoplasia. Definitive diagnosis requires myelography, CT, or MRI.

Nonsurgical treatment is indicated for dogs with mild signs and consists of exercise restriction and prednisone (0.5 mg/kg/day). Signs improve in ~50% of dogs and remained unchanged in ~25% of dogs with nonsurgical treatment. Surgery is indicated in animals with substantial neurologic deficits and in those that do not respond adequately to nonsurgical treatment. The specific technique is based on the changes evident on imaging and include ventral slot with partial discectomy, dorsal laminectomy, or distraction and fusion of affected vertebrae. Overall, ~80% of dogs do well with surgery.

In horses, cervical spondylomyelopathy is the most common noninfectious disease of the spinal cord and occurs in many breeds. Most horses present at <3 yr of age, although they can be affected at any age. The mid-cervical region is most commonly affected, and there is spinal ataxia and tetraparesis. Diagnosis is based on imaging and excluding other causes. Plain radiographs may show abnormal articular facets and stenosis of the vertebral canal. Myelography is necessary for definitive diagnosis and surgical planning. Nonsurgical treatment involves NSAIDs and dimethyl sulfoxide to reduce inflammation. In yearlings, diet modification can help. Surgery most commonly involves ventral fusion of the affected vertebrae. Approximately 80% of affected horses improve with surgery. Owner/rider safety is a major concern in horses with ataxia.

Degenerative Lumbosacral Stenosis:

Narrowing of the lumbosacral vertebral canal or intervertebral foramina results in compression of the cauda equina or nerve roots. It is most common in large breeds of dogs, especially German Shepherds, and is rare in cats. It results from degeneration and protrusion of the L7–S1 disc, hypertrophy of the ligamentum flavum, or rarely subluxation of the lumbosacral joint. The cause is unknown, although German Shepherds with congenital transitional vertebrae are at increased risk. Clinical signs typically begin at 3–7 yr of age and may include difficulty using the pelvic limbs, pelvic limb lameness, tail weakness, and incontinence. Pain on palpation or extension of the lumbosacral joint is the most consistent finding. There may be proprioceptive deficits, muscle atrophy, or a weak flexor reflex in the pelvic limbs. Plain radiographs may show degenerative changes, but definitive diagnosis requires MRI, CT, or epidurography. Dogs in which mild pain is the only sign may improve with 4–6 wk of rest. Epidural injection of methylprednisolone acetate (1 mg/kg on each of day 1, day 14, and day 42) is effective in ~80% of dogs with pain and minimal neurologic deficits. Surgery is indicated when pain is refractory to medical therapy or there are neurologic deficits. The most common technique is dorsal laminectomy with partial discectomy, but foramenotomy or stabilization is indicated in certain cases. Approximately 70%–95% of dogs improve with surgery, although preexisting urinary incontinence may not resolve.

Degenerative Myelopathy of Dogs:

Degenerative myelopathy of dogs, also called chronic degenerative radiculomyelopathy, is a slowly progressive, noninflammatory degeneration of the axons and myelin primarily affecting the white matter of the spinal cord. It is most common in German Shepherds, Pembroke Welsh Corgis, Boxers, Rhodesian Ridgebacks, and Chesapeake Bay Retrievers, but is occasionally recognized in many other breeds. The cause is a mutation in the superoxide dismutase1 (SOD1) gene, inherited in an autosomal recessive pattern with incomplete penetrance. It is similar to familial amyotrophic lateral sclerosis in human patients. Pathologically, there is noninflammatory degeneration of axons in the white matter of the spinal cord, which is most severe in the thoracic region.

Affected dogs are usually >8 yr old and develop an insidious onset of nonpainful ataxia and weakness of the pelvic limbs. Spinal reflexes are usually normal or exaggerated, but in advanced cases there is flaccid tetraparesis and hyporeflexia reflecting lower motor neuron involvement. Early cases may be confused with orthopedic disorders; however, proprioceptive deficits are an early feature of degenerative myelopathy and are not seen in orthopedic disease.

Myelography or MRI and CSF analysis are essential to exclude compressive and inflammatory diseases. A DNA test based on the SOD1 gene is available on the Orthopedic Foundation for Animals Web site ( . Dogs that are homozygous for the mutation are at risk of the disease and will pass one copy of the mutant allele to their offspring. Heterozygotes are at low risk of the disease but have a 50% chance of passing one copy of the mutant allele to each offspring. Homozygous normals are at low risk of the disease and will not pass the mutation to offspring.

There is no specific treatment and no evidence that glucocorticoids, other drugs, or supplements alter the course of the disease. Most dogs are euthanized because of disability within 1–3 yr of diagnosis.

Equine Degenerative Myeloencephalopathy:

Equine degenerative myeloencephalopathy is a progressive neurologic disorder of horses and zebras characterized by diffuse degeneration of axons, myelin, and neurons in the spinal cord and, to a lesser degree, the brain stem. It has been reported in many equine breeds in North America, Australia, and England. The cause is incompletely understood, but a vitamin E deficiency and genetic factors are suspected. Clinical signs usually become apparent during the first year of life and consist of ataxia and weakness in all four limbs, although the hindlimbs may be more severely affected. Clinical signs may stabilize or slowly progress. There is no definitive diagnostic test. Clinical diagnosis is based on clinical features and excluding other causes. Myelography and CSF analysis are normal. Supplementation of pregnant mares and newborn foals with vitamin E is preventive in predisposed families, and affected horses may improve with vitamin E supplementation.

Intervertebral Disc Disease:

Degeneration and subsequent herniation of the intervertebral disc results in compression of the spinal cord, spinal nerve, and/or nerve root. It is a common cause of spinal cord disease in dogs, with a lifetime prevalence of ~3.5%. Clinical signs due to disc disease are rare in cats and horses. Chondrodystrophoid breeds of dogs (eg, Dachshund, Beagle, Shih Tzu, Lhasa Apso, and Pekingese) are most commonly affected, with Miniature Dachshunds having a lifetime prevalence of ~20%. In these breeds, there is chondroid degeneration of the discs within the first few months of life. Disc extrusion can occur as early as 1–2 yr of age, and clinical signs are often acute and severe. In contrast, fibroid disk degeneration typically occurs in large breeds of dogs >5 yr old and causes slowly progressive clinical signs.

The most common sites of disc herniation are the cervical and thoracolumbar regions. The predominant sign of cervical disc herniation is neck pain, manifested as cervical rigidity and muscle spasms. There may be thoracic limb lameness or neurologic deficits, ranging from mild tetraparesis to tetraplegia. In thoracolumbar disc herniation, there may be back pain, evident as kyphosis and reluctance to move. Neurologic deficits are usually more severe than those seen in cervical disc disease and range from pelvic limb ataxia to paraplegia and incontinence. In paraplegic animals, the most important prognostic finding is whether there is deep pain perception caudal to the lesion. This is assessed by pinching the toe or tail and observing whether there is a behavioral response, such as a bark or turn of the head. It is important to pinch the bone to stimulate deep pain receptors, not just the skin, which tests only superficial pain. Reflex flexion of the limb must not be mistaken for a behavioral response.

Definitive diagnosis of disc extrusion is based on imaging studies. Spinal radiographs may show narrowing of the affected disc space, intervertebral foramen or articular facets, or radiodense calcified disc material within the vertebral canal. However, radiographs are not sensitive or specific enough for definitive diagnosis, which requires myelography, MRI, or CT. Dogs with pain and minimal to moderate neurologic deficits often recover with 2–3 wk of cage rest. A short course of prednisone (0.5 mg/kg/day for 3 days) is often helpful in relieving pain. The use of anti-inflammatory or analgesic medication without concurrent cage rest is contraindicated, because an increase in the dog’s activity may lead to further disc extrusion and worsening of spinal cord compression. Clinical signs recur after conservative therapy in 30%–40% of cases.

In animals with severe neurologic deficits, prompt surgery offers the best chance of recovery ( Recovery Rates After Surgery for Intervertebral Disc Disease in Dogs Recovery Rates After Surgery for Intervertebral Disc Disease in Dogs Cervical spondylomyelopathy, also called cervical vertebral malformation-malarticulation and wobbler syndrome, is compression of the spinal cord caused by abnormal development of the cervical... read more Recovery Rates After Surgery for Intervertebral Disc Disease in Dogs ). Other indications for surgery are failure of conservative therapy and recurrent episodes. Hemilaminectomy with removal of the extruded disc material is the most common procedure. Prophylactic fenestration of commonly affected disc spaces (eg, T11 through L4) decreases recurrence in small-breed dogs. Progressive myelomalacia develops in 5%–10% of dogs with paraplegia and loss of deep pain perception. In this syndrome, affected dogs develop flaccid tetraplegia, the level of anesthesia ascends cranially, and respiratory paralysis develops.


Diffuse Idiopathic Skeletal Hyperostosis:

Also known as Forestier disease in human patients, diffuse idiopathic skeletal hyperostosis (DISH) is characterized by ossification of entheses, the sites where a ligament, tendon, or joint capsule inserts into bone. Radiographic criteria for diagnosis are flowing ossification along the ventrolateral aspect of at least four contiguous vertebrae with relative preservation of disc width and absence of facet joint ankylosis. Approximately 4% of dogs >1 yr old are affected, and the prevelance increases with age. As with spondylosis deformans, Boxers are at increased risk, with a prevelance of ~40%. The thoracic and lumbar regions are most commonly affected. It is unclear how often DISH causes clinical signs, and in many cases the radiographic findings are incidental. However, spinal pain and stiffness is possible and, in those cases, treatment is analgesics as needed.

Equine Motor Neuron Disease:

Equine motor neuron disease is a progressive, noninflammatory degeneration of motor neurons in the spinal cord and brain stem of horses. It is most common in the northeastern USA but has been reported in several areas of North and South America, Europe, and Japan. The cause is uncertain, but vitamin E deficiency is a strong risk factor. Adult horses of any age and breed can be affected, although Quarter horses are affected most commonly. Affected horses typically do not have access to pasture grass and are fed poor-quality grass hay.

Clinical signs consist of generalized symmetric weakness, trembling, and muscle atrophy. Affected horses often stand with their head held low and their feet camped under their body, frequently shifting their weight from one limb to another. Ataxia is not a feature of this disease, in contrast to most spinal cord diseases. Many affected horses have retinal abnormalities, including a distinct reticulated pigment pattern and areas of hyperreflectivity. Electromyography and biopsy of the spinal accessory nerve or the sacrodorsalis caudalis muscle are useful in diagnosis.

There is no specific treatment, but some horses improve partially after 2–3 mo of illness. Horses that lack access to green forage high in vitamin E for prolonged periods should be supplemented with vitamin E.

Degeneration of Motor Neurons:

Degeneration of motor neurons is an inherited or sporadic disease seen in Brittany Spaniels, Pointers, German Shepherds, Doberman Pinschers, and Rottweilers; cats; Hereford, Brown Swiss, and red Danish cattle; Yorkshire pigs; and goats. Also called spinal muscular atrophy, this disease is characterized by progressive paresis, tremor, muscle atrophy, and weak spinal reflexes. The age of onset is typically within the first 1−2 yr of life. Electromyography and muscle biopsy help document muscle denervation, but definitive diagnosis is based on loss of motor neurons in the ventral horn of the spinal cord and brain-stem nuclei on necropsy.

Metabolic Storage Disorders:

Rare, usually inherited, metabolic disorders can affect the CNS, including the spinal cord. (Also see Congenital and Inherited Anomalies of the Nervous System Congenital and Inherited Anomalies of the Nervous System read more .)

Spondylosis Deformans:

Spondylosis deformans is a noninflammatory condition characterized by formation of bony projections (enthesophytes) at the location where the annulus fibrosus is attached to the cortical surface of adjacent vertebrae. These bony growths vary from small spurs located several millimeters from the junction between the disc and vertebra to bony bridges that span the disc space, leaving at least part of the ventral surface of the vertebra unaffected. The enthesophytes typically expand laterally and ventrally but not dorsally and therefore rarely affect the spinal cord. The cause is breakdown of the outer fibers of the annulus fibrosis and stretching of the longitudinal ligament. The increased stress at the vertebral attachment of the longitudinal ligament incites bony production.

Spondylosis deformans is seen in dogs, cats, and bulls, and the incidence increases with age. It is uncommon in dogs <2 yr old; by 9 yr of age, 25%–70% of all dogs are affected. It is especially common in Boxers, and a genetic predisposition has been identified in this breed. It is typically an incidental radiographic finding, and there is no correlation between the presence of spondylosis and clinical signs. Rare cases cause spinal hyperesthesia, which should be treated with analgesics.

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Diseases of the Peripheral Nerves and Neuromuscular Junction
Laryngeal paralysis is a common disorder of older, large-breed dogs. Denervation of the cricoarytenoideus dorsalis muscle of the larynx causes the vocal folds and arytenoid cartilages to fail to abduct during inspiration, creating an upper airway obstruction. Although the etiology is usually unknown, trauma and neoplasia can cause laryngeal paralysis. Which of the following conditions can also cause laryngeal paralysis?
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