MSD Manual

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Professional Version

Psychotropic Agents for Integumentary Disease in Animals


Michael Shipstone

, BVSc, FACVSc, DACVD, University of Queensland

Last full review/revision Apr 2022 | Content last modified Jun 2022
Topic Resources

Sedation is the most common adverse effect of diazepam. It is also an appetite stimulant in cats. Idiosyncratic fatal hepatic necrosis has been reported in several cats treated for as few as 8–14 days. Tricyclic antidepressants are potent H1 blockers in addition to inhibiting uptake of serotonin and norepinephrine. These drugs can induce cardiac arrhythmias and lower the seizure threshold. Other adverse effects include dry mouth, hypersalivation, vomiting, constipation, urinary retention, ataxia, disorientation, depression, and anorexia. Tricyclic antidepressants should not be used concurrently with monoamine oxidase inhibitors, including amitraz dips for demodicosis. Dosages should be tapered slowly when discontinued.

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