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Propylene Glycol Toxicosis

By

Gregory F. Grauer

, DVM, MS, DACVIM, Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University

Last full review/revision May 2013 | Content last modified Jun 2016

Although less toxic than EG, ingestion of propylene glycol (PG) may be associated with a toxic syndrome similar to the acute phase of EG toxicosis. The oral LD50 of PG in dogs is ~9 mL/kg. In cats, ingestion of a diet containing 6%–12% PG can result in Heinz body formation and decreased RBC survival. Treatment of PG toxicosis is largely supportive—the use of alcohol dehydrogenase inhibitors is not indicated. Ingestion of PG may result in false-positive EG test kit results.

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Ethylene Glycol Toxicity
All animals are susceptible to poisoning by ethylene glycol, but due to its wide availability and common presence in homes, dogs and cats are most often accidently poisoned. Which of the following common household solvents is the source of ethylene glycol toxicity for companion animals?
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