Primary functions of the urinary system include: 1) excretion of waste products of metabolism; 2) maintenance of a constant extracellular environment through conservation and excretion of water and electrolytes; 3) production of the hormone erythropoietin, which regulates hematopoiesis, 4) production of the enzyme renin, which regulates blood pressure and sodium reabsorption; and 5) metabolism of vitamin D to its active form (1,25-dihydroxycholecalciferol).
Bovine cystitis is a disease of cattle characterized by ascending bacterial infection and inflammation of the urinary tract, with clinical signs including pyuria, hematuria, and stranguria. Some infected animals show signs including decreased appetite and abdominal pain. Treatment is a prolonged course of targeted antimicrobials guided by the results of urine culture and susceptibility testing.
Obstructive urolithiasis is a significant cause of morbidity and mortality in male ruminants. Uroliths form from protein and mineral components of the diet. They develop in the urinary bladder and lodge in the distal sigmoid flexure of cattle and small ruminants or the vermiform appendage (urethral process) of the small ruminant, causing obstruction. Early recognition and treatment are critical to achieving a positive outcome. Urolithiasis is a multifactorial disease, making prevention strategies challenging to develop.
Most infectious diseases of the urinary system in small animals are aerobic bacterial infections. Common organisms include Escherichia coli, Staphylococcus, Enterococcus, and Streptococcus. Less common organisms causing infection include Klebsiella, Proteus, and Pseudomonas. Pasteurella is more common in cats than dogs. Mycoplasma is an uncommon cause of urinary tract infection and is usually found as a coinfection with bacteria. Leptospirosis is a worldwide zoonotic disease caused by filamentous bacteria that infect the kidney and many other organs. Fungi, yeast, and parasites uncommonly infect the urinary system.
Failure of the filtration function of the kidneys leads to the development of azotemia (an excess of nitrogenous compounds in the blood), which may be classified as prerenal, renal, postrenal, or of mixed origin. Prerenal azotemia develops whenever mean systemic arterial blood pressure declines to values