MSD Manual

Please confirm that you are a health care professional

Loading

Nodular Hyperplasia in Small Animals

By

Sharon A. Center

, BS, DVM, DACVIM, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University

Last full review/revision May 2015 | Content last modified May 2015

Nodular hyperplasia (proliferative hepatocytes maintaining single-celled hepatic cord architecture with normal reticulin support) occurs as a benign, age-related microscopic or grossly apparent small mass lesion in dogs. It is often associated with a VH, lacks a defining remodeled border (as characterizes regenerative nodules), and may be confused histologically with adenomatous hyperplasia or hepatic adenoma (demonstrating proliferative disorganized hepatocytes forming thick hepatic cords with diminished reticulin support). Although nodular hyperplasia does not cause clinical disease, it can be accompanied by increased liver enzyme activity, particularly ALP. Unless the liver is diffusely remodeled with nodular lesions (secondary to degenerative VH), TSBA concentrations remain normal. Ultrasonographically, nodular hyperplasia is associated with hypoechoic hepatic nodules set against a hyperechoic background (if associated with glycogen-like VH). Cytology of an aspirate may discriminate dysplastic, neoplastic, or inflammatory cells but cannot exclude any of these disorders. Biopsy is necessary to differentiate between nodular hyperplasia, dysplastic microscopic nodules, regenerative nodules, cirrhosis, and neoplasia.

Others also read

Also of Interest

Videos

View All
Cryptosporidiosis
Video
Cryptosporidiosis
Ascarid parasites, foal
Video
Ascarid parasites, foal
Ascarid parasites visualized within loops of small intestine by transabdominal ultrasound...

SOCIAL MEDIA

TOP