Amino-acetonitrile derivatives are a class of synthetic compounds with high activity against GI nematodes, including isolates resistant to all other commercially available broad-spectrum anthelmintic classes, because of their novel mode of action. Efficacy studies have shown that monepantel (2.5 mg/kg, PO) effectively controls adult and L4 stages of ruminant nematodes, including strains that are resistant or multidrug resistant to the other currently available broad-spectrum anthelmintic classes.
OTHER TOPICS IN THIS CHAPTER
Anthelmintics
Overview of Anthelmintics
Mechanisms of Action of Anthelmintics
Pharmacokinetics of Anthelmintics
Withholding Periods After Anthelmintic Treatment
Safety of Anthelmintics
Resistance to Anthelmintics
Benzimidazoles
Imidazothiazoles
Tetrahydropyrimidines
Macrocyclic Lactones
Salicylanilides, Substituted Phenols, and Aromatic Amide
Praziquantel and Epsiprantel
Amino-acetonitrile Derivatives
Cyclic Octadepsipeptides
Spiroindoles
Miscellaneous Anthelmintics
Combination Anthelmintics