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MSD Manual
Veterinary Manual
The trusted provider of veterinary information since 1955
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Veterinary /
Pharmacology /
Anthelmintics /
... /
Amino-acetonitrile Derivatives /

OTHER TOPICS IN THIS CHAPTER

Anthelmintics
Overview of Anthelmintics
Mechanisms of Action of Anthelmintics
Pharmacokinetics of Anthelmintics
Withholding Periods After Anthelmintic Treatment
Safety of Anthelmintics
Resistance to Anthelmintics
Benzimidazoles
Imidazothiazoles
Tetrahydropyrimidines
Macrocyclic Lactones
Salicylanilides, Substituted Phenols, and Aromatic Amide
Praziquantel and Epsiprantel
Amino-acetonitrile Derivatives
Cyclic Octadepsipeptides
Spiroindoles
Miscellaneous Anthelmintics
Combination Anthelmintics

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Antibacterial Agents
Administration of which of the following systemic antibiotics is most suitable for canine otitis caused by Pseudomonas aeruginosa?

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Amino-acetonitrile Derivatives

By

Jozef Vercruysse

, DVM, Ghent University;


Edwin Claerebout

, DVM, PhD, DEVPC, Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University

Last full review/revision Sep 2014 | Content last modified Oct 2014

Amino-acetonitrile derivatives are a class of synthetic compounds with high activity against GI nematodes, including isolates resistant to all other commercially available broad-spectrum anthelmintic classes, because of their novel mode of action. Efficacy studies have shown that monepantel (2.5 mg/kg, PO) effectively controls adult and L4 stages of ruminant nematodes, including strains that are resistant or multidrug resistant to the other currently available broad-spectrum anthelmintic classes.

© 2020 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA)
Praziquantel and Epsiprantel
Cyclic Octadepsipeptides
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