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MSD Manual
Veterinary Manual
The trusted provider of veterinary information since 1955

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VETERINARY PET
Relationship of Codon Changes in the PNRP Gene to Scrapie Susceptibility or Resistance in Sheep and Goats.

Relationship of Codon Changes in the PNRP Gene to Scrapie Susceptibility or Resistance in Sheep and Goats.

Genotype

Susceptible

Partially Resistant

Resistant

Sheep

(codons 136, 154, 171)

VRQ/VRQ

ARQ/VRQ

ARQ/ARQ

Commonly known as QQ

ARR / heterozygous

AHQ / heterozygous

ARR/ARR,

commonly known as RR

Goats

(codons 146, 222)

NQ/NQ

SQ/SQ

NQ/SQ

NQ/SK

NQ/NK

NK/NK

Unknown

Abbreviations are the standard one-letter abbreviations for amino acids: A, Alanine; H, Histidine; K, Lysine; N, Asparagine; Q, Glutamine; R, Arginine; S, Serine; V, Valine. Codons are listed in numerical order. For example, V136R154Q171 is written as VRQ.

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