CHOP Multidrug Chemotherapy for Treatment of Canine Lymphoma
CHOP Multidrug Chemotherapy for Treatment of Canine Lymphoma
Drug | Dosage | Schedule |
|---|---|---|
l-Asparaginase | 10,000 IU/m2, SC | Wk 1 |
Vincristine | 0.5–0.7 mg/m2, IV | Wk 1, 3, 6, 8, 11, 13, 16, and 18 |
Cyclophosphamide | 250 mg/m2, IV or PO | Wk 2, 7, 12, and 17 |
Doxorubicin | 30 mg/m2, IV, for dogs >10 kg; 1 mg/kg for dogs < 10 kg | Wk 4, 9, 14, and 19 |
Prednisone | 2 mg/kg/day, PO | For first week, then 1.5 mg/kg/day, PO, for 7 days, then 1 mg/kg/day, PO, for 7 days, then 0.5 mg/kg/day, PO, for 7 days, then discontinue. |