Clinical Signs Associated With Organic Herbicides

Clinical Signs Associated With Organic Herbicides

Organic Herbicide Class

Associated Clinical Signs

Anilides, acetamides, amides

Hemolysis, methemoglobinemia, immunotoxicity

Aromatic/benzoic acids

Depression, anorexia, weight loss, weakness, vomiting, diarrhea, acidosis

Biprydil compounds or quaternary ammonium herbicides

Anorexia, gastritis, GI distention, and severe loss of water into the lumen of the GI tract; respiratory distress, excitement, seizures, depression or incoordination

Carbamates, thiocarbamates

Anorexia, depression, dyspnea, increased salivation, diarrhea, weakness, seizures

Dinitrophenols

Fever, dyspnea, acidosis, tachycardia, seizures, coma

Ruminants: methemoglobinemia, hemolysis, hemoproteinemia, yellowing of integument

Imidazolinones

Skeletal myopathy, anemia

Organophosphates

Nausea, vomiting, ataxia, weakness

Phenoxy acid derivatives

Depression, anorexia, weight loss, weakness, vomiting, diarrhea, acidosis

Polycyclic alkanoic acids, aryloxyphenoxypropionics

Irritation

Protoporphyrinogen oxidase inhibitors

Increased porphyrin

Substituted anilines

Ocular, GI, and integument irritation

Triazines, triazoles

Anorexia, hemotoxia, hyperthermia, impaired locomotion, irritation, tachypnea, hypersensitivity

Triazinylsulfonylurea, sulfonylureas

Reduced red blood cell count, reduced hemoglobin, renal impairment, nephrosis

Triazolopyrimidinea

Skin and ocular irritation with potential retinal degeneration

Ureas, thiourea

Hematuria, ataxia, enteritis, weight loss, dyspnea, cyanosis, diarrhea, increased salivation, bruxism, mydriasis

a Timchalk C, Dryzga MD, Johnson KA, et al. Comparative pharmacokinetics of [14C] metosulam (N‐[2, 6‐dichloro‐3‐methylphenyl]‐5, 7‐dimethoxy‐1, 2, 4‐triazolo‐[1, 5a]‐pyrimidine‐2‐sulfonamide) in rats, mice and dogs. J Appl Toxicol. 1997;17(1)9-21). doi:10.1002/(sici)1099-1263(199701)17:1<9::aid-jat390>3.0.co;2-s

a Timchalk C, Dryzga MD, Johnson KA, et al. Comparative pharmacokinetics of [14C] metosulam (N‐[2, 6‐dichloro‐3‐methylphenyl]‐5, 7‐dimethoxy‐1, 2, 4‐triazolo‐[1, 5a]‐pyrimidine‐2‐sulfonamide) in rats, mice and dogs. J Appl Toxicol. 1997;17(1)9-21). doi:10.1002/(sici)1099-1263(199701)17:1<9::aid-jat390>3.0.co;2-s