Dosage Modifications of Aminoglycosides in Renal Failure
Fold Increase Above Normal Serum or Plasma Creatinine Concentration | Dose and Dosage Interval |
|---|---|
2-fold increase | Full dose at usual dosage interval or increase interval to 50% plus usual dosing interval (eg, 36 h) |
3- to 4-fold increase | Full dose at double usual dosage interval |
>4-fold increase | Aminoglycosides contraindicated |