Dosages of Antistaphylococcal Antimicrobials
Dosages of Antistaphylococcal Antimicrobials
Drug | Dosage |
|---|---|
Cephalosporins | |
Cephalexin | 20–30 mg/kg, PO, q 12 h for 21–42 d (treat for 5–7 d beyond resolution of clinical disease or preferably negative culture result) |
Cefadroxil | Dogs: 20 mg/kg, PO, q 12 h for 3–30 d |
Cats: 20 mg/kg, PO, q 24 h for a minimum of 3 weeks | |
Cefaclor | 10–25 mg/kg, PO, q 12 h for 3–30 d |
Cefovecin | 8 mg/kg, SC, q 14 d, repeated as needed if response to therapy is not complete (maximum treatment should not exceed 2 injections)a |
Cefpodoxime | 5–10 mg/kg, PO, q 24 h for 5–7 d or for 2–3 days beyond the cessation of clinical signs (recommended maximum interval is to 28 days) |
Penicillins | |
Amoxicillin-clavulanate | 13.75 mg/kg, PO, q 12 h for 5–7 d |
Oxacillin | 22 mg/kg, PO, q 8 h for 14–21 d |
Fluoroquinolones | |
Enrofloxacin | 5 mg/kg, PO, q 24 h for 7–14 days beyond clinical resolution |
Marbofloxacin | 2 mg/kg, PO, q 24 h for 7–14 days beyond clinical resolution |
Orbifloxacin | 2.5 mg/kg, PO, q 24 h for 7–14 days beyond clinical resolution |
Difloxacin | 5 mg/kg, PO, q 24 h for 7–14 days beyond clinical resolution |
Pradofloxacin | 3 mg/kg, PO, q 24 h for 7–14 days beyond clinical resolution |
Sulfonamides | |
Trimethoprim-sulfadiazine | 15–30 mg/kg, PO, q 12 h for 14–42 d |
Trimethoprim-sulfamethoxazole | 15–30 mg/kg, PO, q 12 h for 14–42 d |
Macrolides | |
Erythromycin | 15–30 mg/kg, PO, q 8 h for 7–10 d |
Clindamycin | Dogs: 10–20 mg/kg, PO, q 12 h for 7–28 d |
Cats: 12.5–25 mg/kg, PO, q 12 h for 7–28 d | |
Lincomycin | 10–20 mg/kg, PO, q 12 h for 12–42 d |
Azithromycin | 10 mg/kg, PO, q 24 h for 5–7 d |
Others | |
Chloramphenicol | 50 mg/kg, PO, q 8 h for 7–14 d |
Rifampin | 5–10 mg/kg, PO, q 12–24 h (duration as needed) |
aZoetis Inc. Convenia injection [product information]. Kalamazoo, MI, USA; 2013. Available at: http://www.drugs.com/vet/convenia.html. Accessed January 26, 2015. |