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Elimination and Distribution of Macrolides

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Learn about SectionName symptoms, diagnosis and treatment in the MSD Manual. HCP and Vet versions too!

Drug	Species	Route	Elimination Half-life (h)	Volume of Distribution (L/kg)	Clearance (mL/kg/min)
Azithromycin	Cats	IV	35	23	10.7
	Dogs	IV	3.5	12	6.0
	Goats	IV	32.5	34.5	14.2
	Horses	IV	15.0	5.6	5.7
	Foals	IV	16.0	22^a	10
Erythromycin	Dogs	IV	1.35	4.8	44
	Horses	IV	1.0	2.3	2.3
	Foals	IV	1.1	7.2	7.2
Tylosin	Swine	IV	4.52	1.4	26.8
	Cattle	IV	3.15	0.789	2.88
	Chickens	IV	0.52	0.69	5.3
Gamithromycin	Cattle	IV	44.9	24.9	11.9
	Swine	IV	16.03	31.03	2.81
Tulathromycin	Calves	IV	65	11.1	3.0
	Swine	IV	69	16.2	3.2
Tildipirosin	Dogs	IV	32.2	28.9	12
	Goats	IV	77.9	24.7	3.6
^aJacks S, Giguère S, Gronwall RR, et al. Pharmacokinetics of azithromycin and concentration in body fluids and bronchoalveolar cells in foals. Am J Vet Res 2001;62:1870–1875.