Elimination, Distribution, and Clearance of Aminoglycosides
Aminoglycoside | Species | Route | Elimination Half-life (min) | Volume of Distribution (L/kg) | Clearance (mL/kg/min) |
|---|---|---|---|---|---|
Gentamicin | Dogs | IV | 81 | 0.19 | 1.73 |
Horses | IV | 99 | 0.17 | 1.41 | |
Neonatal foals | IV | 132 | 0.31 | 1.75 | |
Amikacin | Dogs | IV | 49 | 0.205 | 3.33 |
Horses | IV | 80 | 0.13 | 1.25 | |
Sheep | IV | 85 | 0.335 | 2.71 |