Elimination, Distribution, and Clearance of Cephalosporins
Cephalosporin | Species | Route | Elimination Half-life (min) | Volume of Distribution (L/kg) | Clearance (mL/kg/min) |
|---|---|---|---|---|---|
Cefazolin | Horses | IV | 45 | 0.19 | 5.5 |
Dogs | IV | 180 | 0.383 | 2.5 | |
Cats | IV | 71 | 0.29 | 3.3 | |
Cefotaxime | Sheep | IV | 23 | 0.19 | 8.7 |
Cats | IV | 58 | 0.182 | 2.8 | |
Horses | IV | 36 | 0.29 | 5.2 | |
Cefpodoxime | Dog | IV | 280 | 0.150 | 0.38 |
Cefovecin | Dog | IV | 5.5 days | 0.09 | |
Cats | IV | 7.6 days | 0.09 | 0.006 | |
Cephalexin | Dogs | IV | 117 | 0.37 | 2.83 |
Sheep | IV | 90 | 0.175 | 2 | |
Cefadroxil | Dogs | 120 | — | — | |
Cats | 150–180 | — | — | ||
Horses | IV | 48 | 0.46 | 7 | |
Ceftiofur sodium | Cattle | IV | 216 | 0.393 | 1.3 |
Horses | IV | 6.7 | — | — |