MSD Manual

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Elimination, Distribution, and Clearance of Tetracyclines

Elimination, Distribution, and Clearance of Tetracyclines

Tetracycline

Species

Route

Elimination Half-life (h)

Volume of Distribution (L/kg)

Clearance (mL/kg/min)

Oxytetracycline

Dogs

IV

6

0.24

4.23

Calves (<3 mo old)

IV

10–13

0.91–0.24

1.2–3.45

Cattle

IV

7–10

0.80–1.0

3.33

Horses

IV

8–10

1.1–1.35

2.89

Minocycline

Dogs

IV

6.02

1.46

2.8

Cats

IV

6.66

1.53

2.9

Horses

IV

11.8

1.78

1.74

Doxycycline

Dogs

IV

7–10

1.5

1.7

Swine

IV

6.5

1.0

2.4

Chickens

IV

4.75

0.11

0.67