Natural Steroid Hormone Growth Promotantsa

Hormone

Formb

Dose

Duration of Effect (days)

Growth Response

Potential Adverse Effects

Estradiol + progesterone

Pellet

20 mg estradiol benzoate + 200 mg progesterone (steers)

90–120

10%–15%

Transient increase in sexual behavior

Udder development

Vaginal and rectal prolapse

Ventral edema

10 mg estradiol benzoate + 100 mg progesterone (suckling calves ≤ 400 lb and > 45 days old)c

100–120

3%–5%

Transient increase in sexual behavior

Udder development

Vaginal and rectal prolapse

Ventral edema

Estradiol + testosterone

Pellet

20 mg estradiol benzoate + 200 mg testosterone propionate (heifers)

90–120

5%–15%

Transient increase in sexual behavior

Udder development

Vaginal and rectal prolapse

Ventral edema

Estradiol

Silastic rubber

44 mg estradiol (steers and heifers)

400

10%–15%

Transient increase in sexual behavior

Udder development

Vaginal and rectal prolapse

Ventral edema

26 mg estradiol (steers and heifers)

200

10%–15%

Transient increase in sexual behavior

Udder development

Vaginal and rectal prolapse

Ventral edema

Polylactic acid

28 mg estradiol (steers)

365

10%–15%

Transient increase in sexual behavior

Udder development

Vaginal and rectal prolapse

Ventral edema

a Individual product labeling should be consulted for specific purposes and dosages in food-producing animals.

b Implants must be placed subcutaneously between the ear cartilage and skin to comply with label instructions so that consumption of residues may be avoided.

c The FDA recognizes two subsets of animals within the beef cattle calfhood (suckling) phase: (1) < 2 months old and (2) ≥ 2 months old. US Food and Drug Administration, Classes of Major Food-Producing Animals for New Animal Drug Applications. Accessed November 17, 2023.