MSD Manual

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MSD Manual
Veterinary Manual
The trusted provider of veterinary information since 1955

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VETERINARY PET
Primary Regulators of Calcium Homeostasis

Primary Regulators of Calcium Homeostasis

Hormone

Synthesis Location

Effects on Kidney

Effects on Bone

Effects on Intestine

PTH

Chief cells of parathyroid gland

Calcium reabsorption, phosphorus excretion, increases calcitriol formation

Calcium and phosphorus reabsorption

Increases calcitriol formation, which then increases calcium and phosphorus absorption

Calcitriol

Kidney

Calcium and phosphorus reabsorption

Normal development

Increases calcium and phosphorus absorption

Calcitonin

C cells of thyroid gland

Phosphorus excretion

Inhibits osteoclasts

None

PTHrP

Fetal parathyroid glands, tumors, other tissues

Calcium reabsorption, phosphorus excretion

Growth plate development, calcium and phosphorus reabsorption

None

PTH, parathyroid hormone; PTHrP, parathyroid hormone-related protein

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