MSD Manual

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MSD Manual
Veterinary Manual
The trusted provider of veterinary information since 1955

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VETERINARY PET
Proteins Synthesized, Activated, Regulated, or Cleared by the Liver Impacting Coagulation Status

Proteins Synthesized, Activated, Regulated, or Cleared by the Liver Impacting Coagulation Status

Category

Relevant Proteins

Procoagulants

Fibrinogen, prothrombin, factor V, Factor VII, Factor VIII (vascular origin), Factor IX, Factor X, Factor XI, Factor XII, Factor XIII

Anticoagulants

Antithrombin, Protein C, Protein S, Tissue factor pathway inhibitor

Profibrinolytics

Factor XIIa, Plasmin (derived from circulating plasminogen)

Antifibrinolytics

Plasminogen activator inhibitor-1, Alpha-antiplasmin, Thrombin-activatable fibrinolysis inhibitor

Regulators of platelet production

Thrombopoietin: hormone synthesized in liver; stimulates thrombopoiesis

Merck & Co., Inc., Rahway, NJ, USA (known as MSD outside of the US and Canada) is dedicated to using leading-edge science to save and improve lives around the world.  The Veterinary Manual was first published in 1955 as a service to the community.  The legacy of this great resource continues in the online and mobile app versions today.

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