Topical Therapies for Keratomycosis
Drug | Concentration | Frequency | Notes |
|---|---|---|---|
Fluconazole | 0.2% solution | q 2–6 h | Subconjunctival and intravitreal injections have been described |
Itraconazole | 1% ointment/30% DMSO | q 2–6 h | Does not penetrate anterior chamber |
Miconazole | 1% solution | q 2–6 h | Subconjunctival and intracameral injections have also been described |
Voriconazole | 1% solution | q 2–6 h | Penetrates intact corneal epithelium |
Amphotericin B | 0.075%–5% solution | q 2–6 h | Subconjunctival, intravitreal, and intracameral injections after proper dilution have also been described |
Natamycin | 5% suspension | q 2–6 h | Only FDA-approved drug for fungal keratitis (humans); does not penetrate intact corneal epithelium |
Terbinafine | 1% ointment | q 2–6 h | Not suitable for deep corneal or intraocular mycoses |
Silver Sulfadiazine | 1% ointment/cream | q 6–24 h |