Tricyclic antidepressants

Amitriptyline

Anxiety, compulsive disorders

Cheaper than many other drugs, but may be more likely to cause adverse effects

Clomipramine

Anxiety, aggression, compulsive disorders

FDA approved for use in separation anxiety in dogs

Selective serotonin reuptake inhibitors

Fluoxetine

Anxiety, aggression, compulsive disorders

May take 3 to 4 weeks before affecting behavior; also FDA approved for treating separation anxiety in dogs

Paroxetine

Anxiety, aggression, compulsive disorders

Sertraline

Anxiety, aggression, compulsive disorders

Azapirones

Buspirone

Anxiety

Benzodiazepines

Alprazolam

Thunderstorm phobia, anxiety

Longer acting than other drugs of this class

Diazepam

Anxiety, noise phobia

May cause physical dependence

Monoamine oxidase inhibitors

Selegiline

FDA approved for use in cognitive dysfunction in dogs

Must not be combined with serotonin reuptake inhibitors or tricyclic drugs due to adverse drug interactions