Drugs Used in Aquaculture in the US – Approval Status and Withdrawal Times
Active Ingredient | Trade Name | Generic Use | Application Method | Approval Statusa | Withdrawal Time |
|---|---|---|---|---|---|
Florfenicol | Aquaflor® | Antimicrobial | Medicated feed | FDA approveda (Veterinary Feed Directive) | 15 days |
Oxytetracycline dihydrate | Terramycin-200® | Antimicrobial | Medicated feed | FDA approved (Veterinary Feed Directive) | 21 days |
Ormetoprim sulfadimethoxine | Romet-30® | Antimicrobial | Medicated feed | FDA approved (Veterinary Feed Directive) | 42 days in salmonids; 3 days in catfish |
Hydrogen peroxide (35%) | PEROX-AID® | Antimicrobial (gills and skin only) | Immersion | FDA approved | None |
Chloramine-T | HALAMID Aqua® | Antimicrobial (gills and skin only) | Immersion | FDA approved | None |
Diquat | Reward® | Herbicide Antimicrobial (gills and skin only) | Immersion Immersion | EPA INAD required | 5 days in channel catfish, muskellunge, tiger muskellunge, northern pike; 30 days in all others |
Formalin | Formalin-FTM Formalin-B Parasite-S® | Parasiticide (gills and skin only) | Immersion | FDA approved | None |
Copper sulfate (CuSO4) | Parasiticide (gills and skin only) | Immersion | Unapproved but legally available for use, regulatory action deferred | 7 days | |
Potassium permanganate (KMnO4) | Parasiticide (gills and skin only) | Immersion | Unapproved but legally available for use, regulatory action deferred | 7 days | |
Diflubenzuron | Dimilin® | Parasiticide (external crustaceans) | Immersion | EPAa (restricted use pesticide) | Not for use in food fish |
Tricaine methanesulfonate | Tricaine-S® | Anesthetic | Immersion | FDA approved | 21 days |
Eugenol | Aqui-S20E® | Anesthetic | Immersion | INAD required | 72 hours |
Metomidate | Aquacalm® | Sedative | Immersion | The Index | Not for use in food fish |
Chorionic gonadotropin | Chorulon® | Spawning aid | Injection | FDA approveda (prescription only) | None (broodstock) |
sGnRHa + domperidone | Ovaprim® | Spawning aid | Injection | The Index | Not for use in food fish |
a Approval status as of December 2, 2019. Practitioners should check the FDA website frequently for the most current status of drugs and chemicals. | |||||