Actions of Inflammatory Mediators
Action | Mediatorsa |
|---|---|
Vasodilation, increased vascular permeability | Histamine, serotonin, bradykinin, C3a, C5a, LTC4, LTD4, PGI2, PGE2, PGD2, PGF2, activated Hageman factor, kininogen fragments, fibrinopeptides |
Vasoconstriction | TXA2, LTB4, LTC4, LTD4, C5a |
Smooth muscle contraction | C3a, C5a, histamine, LTB4, LTC4, LTD4, TXA2, serotonin, PAF, bradykinin |
Mast cell degranulation | C5a, C3a |
Stem cell proliferation | IL-3, G-CSF, GM-CSF, M-CSF |
Chemotaxis | C5a, LTB4, IL-8, PAF, 5-HETE, histamine, others |
Lysosomal granule release | C5a, IL-8, PAF |
Phagocytosis | C3b, iC3b |
Platelet aggregation | TXA2, PAF |
Endothelial cell stickiness | IL-1, TNF-alpha, LTB4 |
Granuloma formation | IL-1, TNF-alpha |
Pain | PGE2, bradykinin, histamine, serotonin |
Fever | IL-1, IL-6, TNF-alpha, PGE2 |
a C = complement, LT = leukotriene, PG = prostaglandin, TX = thromboxane, PAF = platelet activating factor, IL = interleukin, CSF = colony stimulating factor, HETE = hydroxyeicosatetraenoate, TNF = tumor necrosis factor | |