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Nutritional Disorders of the Spinal Column and Cord


William B. Thomas

, DVM, MS, DACVIM (Neurology), University of Tennessee

Last full review/revision Oct 2013 | Content last modified Oct 2013

Copper Deficiency:

Deficiency of copper causes CNS disease in sheep, goats, and pigs. Swayback is the congenital form in lambs and is characterized by degeneration and necrosis of the cerebrum. The acquired form, enzootic ataxia, affects lambs, kids, and pigs. Affected animals appear normal at birth but develop progressive paraparesis with hyporeflexia and muscle atrophy within the first few months of life. Other signs include diarrhea and unthriftiness and, in lambs, abnormal fleece. Histologically, there is chromatolysis and loss of neurons and degeneration of axons, primarily in the spinal cord and caudal aspect of the brain stem. Animals may improve with copper supplementation, but permanent neurologic deficits are likely in severely affected animals.

Hypervitaminosis A:

Cats fed excess vitamin A, usually from diets consisting largely of liver, develop extensive exostoses, most prominent in the cervical and thoracic spine. Clinical signs include neck pain and rigidity and forelimb lameness. Vertebral lesions are evident on radiographs. Reduction of dietary vitamin A prevents further exostosis but does not significantly reduce the lesions already present.

Thiamine Deficiency:

Thiamine deficiency is most common in cats but has also been reported in dogs. Causes include inadequately formulated commercial diets, vegetarian diets, food preserved with sulfur dioxide (which destroys thiamine), and raw fish diets (which contain thiaminase). Affected cats typically exhibit brain dysfunction characterized by vestibular signs, head tremor, ataxia, depression, severe ventroflexion of the head, seizures, and death. Clinical signs in dogs include anorexia, depression, paraparesis, seizures, coma, and death. Pathologic findings are polioencephalomalacia, most prominent in the midbrain. Diagnosis is based on clinical signs, dietary history, and response to thiamine administration (thiamine hydrochloride, 10–20 mg/day, IM, in cats; 25–50 mg/day, IM, in dogs).

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Diseases of the Peripheral Nerves and Neuromuscular Junction
Laryngeal paralysis is a common disorder of older, large-breed dogs. Denervation of the cricoarytenoideus dorsalis muscle of the larynx causes the vocal folds and arytenoid cartilages to fail to abduct during inspiration, creating an upper airway obstruction. Although the etiology is usually unknown, trauma and neoplasia can cause laryngeal paralysis. Which of the following conditions can also cause laryngeal paralysis?
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