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Vapor-phase Disinfectants

By

Mark L. Wickstrom

, DVM, MS, PhD, Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan

Last full review/revision Sep 2015 | Content last modified Oct 2015

Alkylating agents such as formaldehyde, ethylene oxide, and propylene oxide are broad-spectrum biocides active against bacteria, viruses, and fungi, including spores.

Ethylene and propylene oxides are highly reactive gaseous fumigants used to sterilize animal feed, human food, surgical equipment that cannot be autoclaved (eg, endoscopes, gloves, syringes, catheters, tubing, implantable devices), laboratory equipment, etc. Both are noncorrosive. However, ethylene oxide has better penetrability than propylene oxide and, therefore, is more commonly used. For this application, ethylene oxide is mixed with chlorofluorocarbons or carbon dioxide and sold in gas cylinders.

Other gaseous disinfectants (eg, formaldehyde, sulfur dioxide, methylbromide) have been used infrequently because of their toxic or corrosive properties.

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