The ideal urine pH should be 7.0–7.5 in dogs and 6.3–6.6 in cats. If the urine pH remains below these values after diet modification, potassium citrate at 80–150 mg/kg/day, PO, divided bid-tid, can be given to increase the pH. Ammonium chloride (200 mg/kg/day, PO, divided tid) and dl-methionine (1,000–1,500 mg/cat/day, PO) are the urinary acidifiers of choice. Chronic urine acidification, and ensuing acidosis, can be harmful and should not be instituted without complete evaluation of the animal.
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