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Drugs Used to Relieve Pain


Sandra Allweiler

, DVM, DACVAA, Department of Clinical Sciences, Carlson College of Veterinary Medicine, Oregon State University

Reviewed/Revised Feb 2020 | Modified Nov 2022

Types of drugs used to relieve pain include opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and alpha2 agonists. As with any other medication, it is always important to follow your veterinarian’s instructions carefully regarding the correct dose to be given.


Opioids (such as morphine) are used by licensed professionals primarily for their pain-relieving effects despite some well-known side effects. These drugs are the most effective analgesics available for the treatment of acute pain in many different animals, particularly cats and dogs.

Opioids relieve pain by acting on the central nervous system. Their side effects, such as sluggishness (sedation), change in mood (good or bad), and excitement, are related to other central nervous system processes. Different species—and even individual animals within a species—respond to opioids in different ways, so doses often require adjustment. For example, a horse might weigh 10 times as much as a large dog, yet the amount of morphine might be similar for both animals. The effect of an opioid depends on additional factors, including whether the animal is in pain, the overall health of the animal, the administration of other drugs at the same time, and individual sensitivity to opioid effects. For some opioids (such as butorphanol), a higher dose does not always bring more pain relief. This is called the ceiling effect.

Nonsteroidal Anti-inflammatory Drugs and Corticosteroids

For many animals, nonsteroidal anti-inflammatory drugs (NSAIDs) are useful as part of a pain management regimen after surgery or to relieve chronic pain, such as that caused by osteoarthritis. Carprofen, firocoxib, and meloxicam are some examples of drugs in this class. NSAIDs work by reducing inflammation, one cause of pain. NSAIDs are readily available, relatively long-acting, and generally inexpensive. They can also be given at home after an animal has been released from the hospital. For these reasons, they have long been used for pain relief. Veterinarians may prescribe NSAIDs as one part of the total plan for pain relief, provided the animal does not have kidney, liver, blood clotting, or stomach problems.

Corticosteroids (such as prednisone and cortisol) also reduce inflammation and provide pain relief. They are used less frequently after surgery because they temporarily weaken the immune system. Other possible side effects of corticosteroids include increased appetite and thirst, and increased need to urinate. Corticosteroids should not be used at the same time as NSAIDs.

Alpha2 Agonists

Alpha2 agonists are used in large animals such as horses to provide both pain relief and sedative effects during procedures in which the animal remains standing. Sedatives calm nervousness and reduce irritability and excitement. Some evidence suggests that the sedative effect lasts longer than the pain relief. Alpha2 agonists include xylazine, medetomidine, detomidine, and romifidine. Using both alpha2 agonists and opioids results in pain relief and sedation that are greater than the effects of either drug alone.

Alpha2 agonists are also used for anesthesia before and during surgery in a variety of animals. However, many veterinarians do not use these drugs to prolong pain relief after surgery or trauma because of the potential for adverse effects. In large animals, alpha2 agonists can cause excessive sedation (such as sleepiness and reduced mental activity) and loss of muscle coordination. In small animals, pain-relieving doses of alpha2 agonists also cause deep sedation. If alpha2 agonists are prescribed after surgery, the dose will be much lower than that used before and during the procedure.

Local Pain Relief

Local anesthetics (such as lidocaine) are used to create an area of numbness in a localized area, such as the area around a wound or surgical site. In large animals, local anesthetics are often used in surgeries—either alone or together with other types of anesthesia—to minimize the potential risks and complications of general anesthesia. In small animals, local anesthetics are usually used for minor procedures such as suturing of cuts. Using local anesthetics before surgery may allow veterinarians to reduce the amount of more powerful general anesthetics needed during longer and more complex surgical procedures. And this can minimize postoperative pain in animals and lead to a faster recovery.

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